ABSTRACT
Objective:To explore therapeutic effects of amlodipine and atorvastatin calcium tablet(AACT)on essen-tial hypertension(EH)complicated coronary heart disease(CHD).Methods:A total of 184 EH + CHD patients treated in our department from May 2015 to May 2016 were selected.According to random number table,patients were randomly and equally divided into amlodipine group and combined treatment group(received AACT treat-ment),both groups were treated for 12 months.Blood pressure,blood lipid levels,carotid intima-media thickness (IMT),plasma concentrations of nitric oxide(NO)and endothelin(ET)-1 were measured and compared between two groups before and after treatment.Results:Compared with amlodipine group after 12-month treatment,there were significant reductions in levels of systolic blood pressure[(135.0 ± 3.9)mmHg vs.(129.0 ± 4.1)mmHg],di-astolic blood pressure[(87.0 ± 4.8)mmHg vs.(82.0 ± 4.1)mmHg],total cholesterol[(5.44 ± 1.09)mmol/L vs. (4.31 ± 1.03)mmol/L],triglyceride[(1.59 ± 0.50)mmol/L vs.(1.01 ± 0.55)mmol/L],low density lipoprotein cholesterol[(2.89 ± 0.35)mmol/L vs.(2.12 ± 0.22)mmol/L]and plasma ET-1[(50.9 ± 5.3)ng/L vs.(47.0 ±6.7)ng/L],and significant rise in levels of high density lipoprotein cholesterol[(1.19 ± 0.21)mmol/L vs.(1.44 ± 0.21)mmol/L]and plasma NO[(70.8 ± 6.9)μmol/L vs.(129.1 ± 4.1)μmol/L]in combined treatment group, P=0.001 all;there was no significant difference in carotid IMT between two groups(P=0.980).No severe ad-verse reactions were found in two groups.Conclusion:Amlodipine and atorvastatin calcium tablet can significantly reduce levels of blood pressure and blood lipids in patients with hypertension complicated coronary heart disease.It possesses stronger protective effect on vascular function,which is worth extending.
ABSTRACT
Objective To study changes of phosphorylated cyclic adenosine monophosphate(c-AMP) response element binding protein in hippocampus(CA1) of neonatal rats after cerebral hypoxic-ischemia(HI)and effects of gangliosides (GM1)on the p-CREB.Methods An animal model of neonatal hypoxic-ischemia brain damage was established. Changes of p-CREB in hippocampal CA1 was detected with immunohistochemical methods.Results The p-CREB levels in the CA1 of HI and GM1 groups increased transiently and then decreased quickly, but there was no significant difference between HI and GM1 group.Conclusion The p-CREB levels in the CA1 of HI group increase transiently and then decrease quickly after HI ;GM1 has little effect on p-CREB in the CA1 after HI.
ABSTRACT
Objective To study expressions of heme oxygenase-1 mRNA and protein in rat hippocampus after hypoxic-ischemia brain damage(HIBD) as well as the relationship with apoptosis in brain.Methods Seven-day-old SD rats were randomly divided into hypoxic-ischemia brain damage group and sham control group.Expressions of HO-1 protein and mRNA as welll as the relationship with apoptosis after HIBD in neonatal rat were determined by immunohisochemistry and in situs hybridizaion as well as terminal deoxynucleotidy transferase mediated UTP-biotin nick end labeling(TUNEL).Results 1.In the right hippocampus,expression of HO-1 gene increased sharply at 4 h (P